栗琳 Ph.D

Assistant Professor, School of Life Science, Tsinghua University

清华大学 生命科学学院 助理教授

Founder, Beijing Health Biotech. Co.,Ltd.

北京豪思生物科技有限公司 创始人

EDUCATION

主要教育经历

University of Cambridge Ph.D. in Proteomics                                             2010-2013

剑桥大学 博士学位 蛋白组药学方向

University of Magdeburg, Master in Neurobiology                                      2007-2010

马德堡大学 硕士学位 神经生物学方向

Peking University, Bachelor in Biochemistry                                               2003-2007

北京大学理学学士学位 生化学方向

WORKING AND RESEARCH EXPERIENCE

主要工作经历

Ø Founder, Health Biotech.                                                                 2016-current

豪思生物 创始人 2016年至今

Health Biotech’s (“H.B.”) mission is to enrich the health and vitality of humankind (especially the Alzheimer's patients) through newly developed diagnostic tests and therapies. Using advanced proteomics platform, H.B. is developing and looking for biomarkers derived from blood and its components with a focus to improve early diagnosis of neurological and cardiovascular diseases such as Alzheimer's disease. H.B. is a leading proteomics central lab service provider in China, servicing top hospitals and diagnostics centers in Beijing. It provides comprehensive proteomical testing services in China and is considered as a leader in this field. Independent clinical proteomical diagnostic is an established market in U.S, Western Europe and Japan as well as other developed area. However in China, the market just started. H.B.’s aim is to import the well-established proteomical tests into China healthcare systems and to search for the new biomarkers base upon the largest and the fastest-growing diagnosed sufferers in China.

豪思生物的使命是通过开发基于质谱技术的体外诊断试剂和第三类医疗技术疗法，改善和提高神经类疾病病人，特别是阿尔茨海默症患者的健康状况和生活质量。公司采用世界最先进的质谱组学平台，开发和寻找血液中与心脑血管和神经系统疾病相关的特异的早期诊断生物标志物。

豪思生物同时还是一家技术领先的质谱组学实验服务供应商，服务于国内顶尖的医院和临检中心，提供全面的临床代谢组，酯组和蛋白组学检测服务，被认为是这一领域的领导者之一。独立的临床质谱组学诊断实验室（Clia Lab）在美国和欧洲等发达地区已经建立了成熟的体制和市场，而在中国才刚刚开始。豪思生物的目标是将西方成熟的检测项目和技术引进至国内的医疗体系中，同时将基于中国大量临床病例自主研发的创新检测国际化。

Ø Principal Investigator, Tsinghua University                                       2014-2019

清华大学 学术带头人

Established “LiLin Lab” in School of Medicine, Tsinghua University, answering the proteomics scientific questions, published more than 30 papers in international journals, including top international journals such like《Proceedings of the National Academy of Sciences 》,《Brain Structure Function》and《Proteomics》. Total impact factors:107; 8 patents.

2014年入选清华北大生命联合中心 “青年学者”项目, 在清华医学院建立了“栗琳 lab”解决蛋白组学问题并在国际知名期刊杂志中发表论文 30 余篇， 其中包括科学界权威杂志《美国国家科学院院刊》、《大脑结构功能》、 《蛋白组学》等，总影响因子达到 107。专利2 8 件。

Ø Assistant Professor, Medical University of Vienna                               2014-2015

维也纳医科大学 助理教授

Principal Investigator in Neuroproteomics Medical University of Vienna    2012-2015

维也纳医科大学 神经蛋白组学交叉学科负责人

In charge of  a research team, which has six scientists and Ph.D students.

•管理由 6 名科学家和博士生组成的研究团队

Supervised all projects and trouble shootings.

•监控全部项目的执行过程，并负责解决相关问题

Actively communicated with the team to facilitate the interaction and communication.

•与团队积极沟通，促进团队内的互动和交流

Generated all project ideas in the department of neuroscience and designed and developed research projects.

•发起并主管神经科学部门的所有项目，构思并制定研究课题

Ø Scientific Consultant, RedBull GmbH.                                                 2009-2015

红牛公司 科学顾问

In charge of the development of cognitive enhancers.

负责提高记忆力产品的研发。

RESEARCH DIRECTION

研究方向

1. Neurobiological mechanism of cognitive enhancers, especially for Alzheimer's disease

提高记忆力药物的研发及其神经生物学机制，尤其是减缓老年痴呆药物的机制

2. Molecular mechanism of antidepressants

抗抑郁药物的研发和抑郁的分子机制

3.Signalling pathways of protease phosphorylation in the brain

蛋白酶磷酸化机制对大脑各通路的作用机理

4. Molecular machinery of learning and memory

学习和记忆的分子机制

5. Biomarkers for diseases in the biological fluid

血液中疾病生物标志物的研发

OTHERS

学会任职

1. Member of the editorial board of 《 Amino Acid》（IF:3.914）2009-2014

《氨基酸》杂志 （IF:3.914）编辑委员会成员 2009 - 2014

2. Invited reviewer: Plos One, Neurochemistry International, Fontier in Neuroscience ,etc.

学术刊物特邀审稿人：公共科学图书馆期刊，国际神经化学， Fontier in Neuroscience杂志等。

3. President  of the international conference for Amino Acid, Peptides and Proteins The meeting was successfully held in Greece in 2008 (100 participants), in Austria in 2010 (500 participants), and in China in  2012 (350 participants)

两年一届的氨基酸，多肽和蛋白质大会主办方负责人。成功地在希腊 2008 (100 人参会)， 奥地利 2010（500 人参会）和中国 2012（350 人参会）举办年会

4. Youth Council of Future Forum.

The Future Forum is the only cross-fields nonprofit platform to promote science and scientists in China: it communicates science to the public, connects the scientific field with the market and catalyzes private funds to support scientific research.

Since its initiation, Future Forum adheres to the mission of "Transform the Future with Science", aiming to give the public nonprofit platform a deeper connotation and unique value in the fast-changing times. Today, Future Forum has become one of the most authoritative public science platforms in China.

未来论坛 青年理事

未来论坛是当前中国最具声望的民间科学公益组织，由一群崇尚科学、热心公益的科学家、企业家于2015年共同发起创立。自成立以来，未来论坛秉承“弘扬科学精神，助力科创兴国”的宏伟使命，全面推动产学研资政融合和大众科普事业发展，矢志作为科学面向公众的“传播人”、科学界和产业界的“对接人”、以民间资本激励科学突破的“推动人”。迄今已凝聚了数百位全球杰出科学家、顶尖投资人和卓越产业领袖，是中国唯一的商学跨界的科学公益平台。未来论坛于2016年创设未来科学大奖，奖励主要在大中华地区做出具有国际影响力的原创科研工作的科学家。

5. 中国医学装备学会检验医学分会第二届创新技术与评估学组委员

6. 北京市临床检验中心第一届临床质谱规范化应用专家委员会顾问委员

7. Member of the Alzheimer’s Disease Association

阿尔兹海默病协会会员

8. Cover figure of the journal《Protein and Proteomics》（《Hippocampus》(IF: 5.492) No. 22, 2012）

杂志 Hippocampus (IF: 5.492) 2012 年 22 期 《蛋白及蛋白组学》专刊的特邀编委及封面人物